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HPHC Testing

Regardless of whether your products are e-cigarettes (ENDS), e-liquids, e-vapor devices (ENDS), cigarettes, oral tobacco products, gels or tobacco free oral nicotine products, Labstat offers validated methods for every chemical on the FDA’s HPHC list (Harmful and Potentially Harmful Constituents). Our validation process is designed to meet regulatory standards to ensure that submitted data is reliable and defensible.

HPHC Testing Services

Group Instrument Analytes
Aromatic Amines GC-MS (NCI) or GC-MS 1-aminonaphthalene, 2,6-dimethylaniline, 2-aminonaphthalene, 4-aminobiphenyl, o-anisidine, o-toluidine
Caffeic acid HPLC-UV caffeic acid
Carbonyls GC-MS (SIM) acetaldehyde, acetone, acrolein, crotonaldehyde, formaldehyde, methyl ethyl ketone, propionaldehyde,
Nicotine degredation products LC-MS/MS anabasine, nornicotine
Aromatic amines, heterocyclic LC-MS/MS 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ), 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC), 2-amino-6-methyldipyrido[1,2-a:3’,2’-d]imidazole (Glu-P-1), 2-amino-9H-pyrido[2,3-b]indole (AαC), 2-aminopyrido[1,2-A:3’,2’-D]imidazole (Glu-P-2), 3-amino-1,4-dimethyl-5H-pyrido[4,3-b] indole (Trp-P-1), 3-amino-1-methyl-5H-pyrido[4,3-b] indole (Trp-P-2)
Hydrogen cyanide CFA HCN impinger, HCN pad, total HCN
Metals, mercury CVAA mercury
Hydrazine LC-MS/MS hydrazine
Metals ICP-MS arsenic, beryllium, cadmium, chromium, cobalt, lead, nickel, selenium
Ammonia IC Ammonia
Polynuclear aromaric hydrocarbons and aza-arenes GC-MS (SIM) 5-methylchrysene, dibenz(a,e)pyrene, dibenz(a,h)pyrene, dibenz(a,i)pyrene, dibenz(a,l)pyrene
Polynuclear aromaric hydrocarbons GC-MS (SIM) benzo(a)anthracene, benzo(a)pyrene, benzo(b)fluoranthene, benzo(c)phenanthrene, benzo(j)aceanthrylene , benzo(k)fluoranthene, chrysene, cyclopenta(c,d)pyrene, dibenz(a,h)anthracene, indeno(1,2,3-cd)pyrene, naphthalene
Phenols HPLC-FLU catechol, m-cresol, o-cresol, p-cresol, phenol
Radionucleotides polonium-210 (sub-contracted)
Volatiles, semi GC-MS (SIM) acetamide, acrylamide, benzo(b)furan, nitrobenzene, quinoline, styrene
Volatiles, semi GC-MS (TQU) ethyl carbamate
NFDPM, nicotine and CO NFDAM, nicotine, water, carbon monoxide, TPM
Nitrosamines, tobacco specific LC-MS/MS 4-[methyl(nitroso)amino]-1-(3-pyridinyl)-1-butanone (NNK), N-nitrosonornicotine (NNN)
Radionucleotides uranium-235, uranium-238 (sub-contracted)
Nitrosamenes, volatile LC-MS/MS 1-nitrosopiperidine (NPIP), N-nitrosodiethanolamine (NDELA), N-nitrosodiethylamine (NDEA), N-nitroso-dimethylamine (NDMA), N-nitrosomorpholine (NMOR), N-nitroso-N-methylethylamine (NEMA), N-nitrosopyrrolidine (NPYR
Volatiles GC-MS (SIM) 1,3-butadiene, acrylonitrile, benzene, ethylbenzene, ethylene oxide, furan, isoprene, nitromethane, propylene oxide, toluene, vinyl acetate, vinyl chloride
Volatiles GC-TEA 2-nitropropane