Residual Solvent Testing

The presence of residual solvents and/or volatile organic impurities can be verified and quantified using headspace GC-MS/headspace GC-FID. Our method is capable of identifying and quantifying all Class 1, Class 2, and Class 3 solvents specified in USP <467> Residual Solvents.

The following solvents can be quantified:

Class 1

  • Benzene
  • Carbon tetrachloride,
  • 1,2-Dichloroethane,
  • 1,1-Dichloroethane
  • 1,1,1-Trichloroethane

Class 2

  • Acetonitrile,
  • Chlorobenzene,
  • Chloroform,
  • Cyclohexane
  • 1,2-Dichloroethane
  • 1,2-Dimethoxyethane
  • N,N-Dimethylacetamide
  • N,N-Dimethylformamide
  • 1,4-Dioxane
  • 2-Ethoxyethanol
  • Ethylene glycol
  • Formamide
  • Hexane
  • Methanol
  • 2-Methoxyethanol
  • Methylbutylketone
  • Methylcylohexane
  • Methylene chloride
  • N-Methylpyrrolidone
  • Nitromethane
  • Pyridine
  • Sulfolane
  • Tetrahydrofuran
  • Tetralin
  • Toluene
  • Trichloroethylene
  • Xylene

Class 3

  • Acetic acid
  • Acetone
  • Anisole
  • 1-Butanol
  • 2-Butanol
  • Butyl acetate
  • tert-Butylmethyl ether
  • Cumene
  • Dimethyl sulfoxide
  • Ethanol
  • Ethyl acetate
  • Ethyl ether
  • Ethyl formate
  • Formic acid
  • Heptane
  • Isobutyl acetate
  • Isopropyl acetate
  • Methyl acetate
  • 3-Methyl-1-butanol
  • Methylethylketone
  • Methylisobutylketone
  • 2-Methyl-1-propanol
  • Pentane
  • 1-Pentanol
  • 1-Propanol
  • 2-Propanol
  • Propyl acetate