Residual Solvent Testing
The presence of residual solvents and/or volatile organic impurities can be verified and quantified using headspace GC-MS/headspace GC-FID. Our method is capable of identifying and quantifying all Class 1, Class 2, and Class 3 solvents specified in USP <467> Residual Solvents.
The following solvents can be quantified:
Class 1
- Benzene
- Carbon tetrachloride,
- 1,2-Dichloroethane,
- 1,1-Dichloroethane
- 1,1,1-Trichloroethane
Class 2
- Acetonitrile,
- Chlorobenzene,
- Chloroform,
- Cyclohexane
- 1,2-Dichloroethane
- 1,2-Dimethoxyethane
- N,N-Dimethylacetamide
- N,N-Dimethylformamide
- 1,4-Dioxane
- 2-Ethoxyethanol
- Ethylene glycol
- Formamide
- Hexane
- Methanol
- 2-Methoxyethanol
- Methylbutylketone
- Methylcylohexane
- Methylene chloride
- N-Methylpyrrolidone
- Nitromethane
- Pyridine
- Sulfolane
- Tetrahydrofuran
- Tetralin
- Toluene
- Trichloroethylene
- Xylene
Class 3
- Acetic acid
- Acetone
- Anisole
- 1-Butanol
- 2-Butanol
- Butyl acetate
- tert-Butylmethyl ether
- Cumene
- Dimethyl sulfoxide
- Ethanol
- Ethyl acetate
- Ethyl ether
- Ethyl formate
- Formic acid
- Heptane
- Isobutyl acetate
- Isopropyl acetate
- Methyl acetate
- 3-Methyl-1-butanol
- Methylethylketone
- Methylisobutylketone
- 2-Methyl-1-propanol
- Pentane
- 1-Pentanol
- 1-Propanol
- 2-Propanol
- Propyl acetate